KISDD 2.0 is a unique knowledge-based in silico drug discovery platform for screening new drug candidates for the treatment of a disease. The platform establishes drug discovery strategy through the holistic understanding of diseases. It uses huge amount of databases, profound knowledge information and high-performance computing technology to find out effective drug candidates. When drug candidates are found by the platform, we first confirm the efficacy and identify the mechanism of action. And then we conduct biological experiments necessary for the development of a new drug.